Article

OTX2 controls chromatin accessibility to direct somatic versus germline differentiation

2025-02-18

Abstract excerpt

<h4>Summary</h4> The choice between somatic and germline fates is essential for species survival. This choice occurs in embryonic epiblast cells, as these cells are competent for both somatic and germline differentiation. The transcription factor OTX2 regulates the choice between somatic and germline fates, as Otx2 -null epiblast-like cells (EpiLCs) form primordial germ cell-like cells (PGCLCs) with enhanced eff...

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Literature Corpus work: b38bbc90-1331-562e-bfdb-8a7fb00061bb
DOI: 10.1101/2025.02.18.638827

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