Article

The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine Development

2018-09-24

Abstract excerpt

Lineage-restricted transcription factors, such as the intestine-specifying factor CDX2, often have dual requirements across developmental time. Embryonic-loss of CDX2 triggers homeotic transformation of intestinal fate, while adult-onset Cdx2 -loss compromises critical physiological functions but preserves intestinal identity. It is unclear how such diverse requirements are executed across the developmental conti...

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Literature Corpus work: 175f999e-5c28-5005-b415-4a93099ac50a
DOI: 10.1101/425827

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