Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development

Abstract excerpt

Maldevelopment of the pharyngeal endoderm, an embryonic tissue critical for patterning of the pharyngeal region and ensuing organogenesis, ultimately contributes to several classes of human developmental syndromes and disorders. Such syndromes are characterized by a spectrum of phenotypes that currently cannot be fully explained by known mutations or genetic variants due to gaps in characterization of critical...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Congenital Diaphragmatic Hernia Studies
• Share to Neonatal Respiratory Health Research
• Share to Tracheal and airway disorders