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Article

Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration.

eLife - 28 Jun 2018

Collins Michelle M, Maischein Hans-Martin, Dufourcq Pascale, Charpentier Marine, Blader Patrick, Stainier Didier Yr

Abstract excerpt

Pitx2c, a homeodomain transcription factor, is classically known for its left-right patterning role. However, an early wave of pitx2 expression occurs at the onset of gastrulation in several species, indicating a possible earlier role that remains relatively unexplored. Here we show that in zebrafish, maternal-zygotic (MZ) pitx2c mutants exhibit a shortened body axis indicative of convergence and extension (CE)...

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Identifiers

PMID: 29952749
DOI: 10.7554/eLife.34880
PMCID: PMC6023614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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