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The Role of Somatic Mutations in Ischemic Stroke: CHIP’s Impact on Vascular Health

27 Jan 2025

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is increasingly recognized as a significant contributor to ischemic stroke and other cardiovascular diseases due to its association with somatic mutations in hematopoietic cells. These mutations, notably in genes like DNMT3A, TET2, and JAK2, induce pro-inflammatory and pro-atherosclerotic processes, promoting vascular damage and stroke risk. With the...

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PMID: 39997650
DOI: 10.3390/neurolint17020019

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