Article

The kidney protects against sepsis by producing systemic uromodulin

2021-01-09

Abstract excerpt

Sepsis is a significant cause of mortality in hospitalized patients. Concomitant development of acute kidney injury (AKI) increases sepsis mortality through unclear mechanisms. While electrolyte disturbances and toxic metabolite buildup during AKI could be important, it is possible that the kidney produces a protective molecule lost during sepsis with AKI. We previously demonstrated that systemic Tamm-Horsfall Pro...

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Literature Corpus work: 261a46f6-07ce-5b0b-9c5f-20689afccc8f
DOI: 10.1101/2021.01.08.425960

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