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The kidney releases a non-polymerizing form of Uromodulin in the urine and circulation that retains the external hydrophobic patch domain

2021-03-02

Abstract excerpt

Uromodulin (Tamm-Horsfall protein, THP) is a glycoprotein uniquely produced in the kidney. It is released by cells of the thick ascending limbs (TAL) apically in the urine, and basolaterally in the renal interstitium and systemic circulation. Processing of mature urinary THP, which polymerizes into supra-molecular filaments, requires cleavage of an external hydrophobic patch (EHP) at the C terminus. However, THP i...

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Identifiers and source

Literature Corpus work
7f47cad2-809b-534e-af86-d4769c7b8eca
DOI
10.1101/2021.02.26.21251982
Open publication

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