Article
Uromodulin promotes immune zonation and inhibits alternative inflammasome-mediated activation of immune-to-collecting duct inflammatory signaling in early acute kidney injury
2026-03-01
Abstract excerpt
Uromodulin, a protein made uniquely by the kidney, is protective against acute kidney injury. An integrated transcriptomic and multiplexed spatial protein imaging was used to uncover early cellular and molecular pathophysiological mechanisms following murine kidney ischemia and reperfusion injury (IRI) and better define the role of Uromodulin at the early stage of injury. Six hours following IRI, there was a pan-n...
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Identifiers and source
- Literature Corpus work
- d7e91c3c-f95b-50ed-bf16-456f45c109b0
- DOI
- 10.64898/2026.02.26.708299