Article
Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury.
JCI insight - 8 Dec 2025
Kumar Avnee J, Epler Katharine, Wang Jing, Shen Alice, Samandari Negin, Rolfsen Mark L, Barnes Laura A, Shadel Gerald S, Moyzis Alexandra G, Sainz Alva G, Ulubabyan Karlen, Li Kefeng, Jepsen Kristen, Li Xinrui, Fuster Mark M, Spragg Roger G, Sasik Roman, Vallon Volker, Goodluck Helen, Ix Joachim H, Singh Prabhleen, Hepokoski Mark L
Abstract excerpt
Mitochondrial dysfunction is a major mechanism of acute kidney injury (AKI), and increased circulating interleukin 6 (IL-6) is associated with systemic inflammation and death due to sepsis. We tested whether kidney mitochondrial DNA (mtDNA) contributes to IL-6 release in sepsis-associated AKI via Toll-like receptor 9 (TLR9). In a murine model of sepsis via cecal ligation and puncture (CLP), we used...
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