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Article

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.

Journal of the American Society of Nephrology : JASN - 1 Mar 2018

Micanovic Radmila, Khan Shehnaz, Janosevic Danielle, Lee Maya E, Hato Takashi, Srour Edward F, Winfree Seth, Ghosh Joydeep, Tong Yan, Rice Susan E, Dagher Pierre C, Wu Xue-Ru, El-Achkar Tarek M

Abstract excerpt

Tamm-Horsfall protein (THP), also known as uromodulin, is a kidney-specific protein produced by cells of the thick ascending limb of the loop of Henle. Although predominantly secreted apically into the urine, where it becomes highly polymerized, THP is also released basolaterally, toward the interstitium and circulation, to inhibit tubular inflammatory signaling. Whether, through this latter route, THP can also...

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Identifiers

PMID: 29180395
DOI: 10.1681/ASN.2017040409
PMCID: PMC5827593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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