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Article

Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes.

Critical care (London, England) - 18 Dec 2024

Stanaway Ian B, Morrell Eric D, Mabrey F Linzee, Sathe Neha A, Bailey Zoie, Speckmaier Sarah, Lo Jordan, Zelnick Leila R, Himmelfarb Jonathan, Mikacenic Carmen, Evans Laura, Wurfel Mark M, Bhatraju Pavan K

Abstract excerpt

BACKGROUND: Patients with sepsis-induced AKI can be classified into two distinct sub-phenotypes (AKI-SP1, AKI-SP2) that differ in clinical outcomes and response to treatment. The biologic mechanisms underlying these sub-phenotypes remains unknown. Our objective was to understand the underlying biology that differentiates AKI sub-phenotypes and associations with kidney outcomes. METHODS: We prospectively enrolled...

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Identifiers

PMID: 39695715
DOI: 10.1186/s13054-024-05202-9
PMCID: PMC11654061

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