Article

Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferation

2025-08-05

Abstract excerpt

<h4>Aims/hypothesis</h4> Type 1 diabetes is an autoimmune disease caused by immune-mediated destruction of insulin-producing pancreatic beta cells. Interestingly, individuals with long-standing type 1 diabetes have residual beta cells, suggesting the existence of regenerative mechanisms that help maintain beta cell survival. Islet-resident macrophages have an important role in type 1 diabetes, and during disease...

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Literature Corpus work: 2602f7b0-4996-51c9-a95d-4dc3e2934b23
DOI: 10.1101/2025.08.04.668458

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