Article
Islet macrophages drive islet vascular remodeling and compensatory hyperinsulinemia in the early stages of diabetes
2019-03-21
Abstract excerpt
β-cells respond to peripheral insulin resistance by increasing circulating insulin in early type-2 diabetes (T2D). Islet remodeling supports this compensation but the drivers of this process remain poorly understood. Infiltrating macrophages have been implicated in late stage T2D but relatively little is known on islet resident macrophages, especially in early T2D. We hypothesize that islet resident macrophages co...
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Identifiers and source
- Literature Corpus work
- ec4cbdab-767c-5458-96f0-6da501320c17
- DOI
- 10.1101/584953