Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury.

EBioMedicine - 1 Aug 2020

Wu Jinghua, Zhang Li, Shi Juanjuan, He Ruizhe, Yang Wenjuan, Habtezion Aida, Niu Ningning, Lu Ping, Xue Jing

Abstract excerpt

BACKGROUND: Impaired or hyperactive pancreas regeneration after injury would cause exocrine insufficiency or recurrent / chronic pancreatitis and potentially carcinogenesis. Macrophages are the most abundant immune cells in the regenerative pancreas, however their phenotype and role remain poorly defined. METHOD: Using caerulein-induced acute pancreatitis (AP) model, we examined the dynamic landscape of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Interleukin-4 Receptor alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liposomes

Share to Liver Regeneration

Share to Pancreatitis

Share to Receptors, Cell Surface

Share to Sequence Analysis, RNA

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 32739869
DOI: 10.1016/j.ebiom.2020.102920
PMCID: PMC7399125

Genes

ADM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury.PMID 32739869Read ↗

Macrophages in the pancreas: Villains by circumstances, not necessarily by actions.Semantic proximity Read ↗

Novel Circulating and Tissue Monocytes as Well as Macrophages in Pancreatitis and Recovery.Semantic proximity Read ↗

Dynamic remodeling of the pancreas immune landscape in obesitySemantic proximity Read ↗

Dynamic remodeling of the pancreas immune landscape in obesitySemantic proximity Read ↗

Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.Semantic proximity Read ↗

Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferationSemantic proximity Read ↗

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis.Semantic proximity Read ↗

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.Semantic proximity Read ↗

Integration of scRNA-Seq and Bulk RNA-Seq Reveals Molecular Characterization of the Immune Microenvironment in Acute PancreatitisSemantic proximity Read ↗

Macrophage Phenotype in Liver Injury and RepairSemantic proximity Read ↗

The Pathogenesis of Pancreatitis and the Role of AutophagySemantic proximity Read ↗

IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.