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Interactions between islet-resident macrophages and β cells in diabetes

28 Jul 2025

Abstract excerpt

In diabetes, islet-resident macrophages (IRMs) and β cells engage in multifaceted interactions through diverse signaling pathways and cell-cell contact within the islet microenvironment, jointly shaping both homeostasis and disease progression. This review first outlines the origin, renewal dynamics, and phenotypic heterogeneity of IRMs, highlighting their essential roles in maintaining metabolic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40791590
DOI: 10.3389/fimmu.2025.1630507

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