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Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes

22 May 2015

Abstract excerpt

Chronic systemic inflammation is a hallmark feature of obesity and type 2 diabetes. Both resident and recruited islet macrophages contribute to the proinflammatory milieu of the diabetic islet. However, macrophages also appear to be critical for β-cell formation during development and support β-cell replication in experimental models of pancreas regeneration. In light of these findings, perhaps macrophages in the...

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PMID: 26001058
DOI: 10.1210/me.2014-1393

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