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Article

Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligase

2026-03-15

Abstract excerpt

The vertebrate CRL4 family of Cullin-RING E3 ubiquitin ligases is distinguished from other cullin-based ligases by the presence of two highly homologous paralogs, CUL4A and CUL4B. Both CRL4 complexes use the DDB1 subunit to recruit dedicated and interchangeable substrate receptors called DCAFs, but the underlying mechanisms guiding DCAF specificity for CUL4B or CUL4A remain poorly understood. Here, we performed st...

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Identifiers and source

Literature Corpus work
dc1286b0-b5fd-59e7-95a3-148de8060ec6
DOI
10.64898/2026.03.13.711546
Open publication

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Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligaseDOI 10.64898/2026.03.13.711546
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