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Article

Structural insights into the functional diversity of the CDK–cyclin family

1 Sept 2018

Abstract excerpt

Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabolism and cell differentiation. The cyclins, though originally characterized as CDK partners, also have CDK-independent roles that include the regulation of DNA damage...

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PMID: 30185601
DOI: 10.1098/rsob.180112

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