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Article

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus.

Nature - 29 Apr 1999

Visintin R, Hwang E S, Amon A

Abstract excerpt

In eukaryotes, the activation of mitotic cyclin-dependent kinases (CDKs) induces mitosis, and their inactivation causes cells to leave mitosis. In budding yeast, two redundant mechanisms induce the inactivation of mitotic CDKs. In one mechanism, a specialized ubiquitin-dependent proteolytic system (called the APC-dependent proteolysis machinery) degrades the mitotic (Clb) cyclin subunit. In the other, the...

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Identifiers

PMID: 10235265
DOI: 10.1038/19775

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus.PMID 10235265Read ↗

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.Semantic proximity Read ↗

APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.Semantic proximity Read ↗

Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication.Semantic proximity Read ↗

The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.Semantic proximity Read ↗

Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation.Semantic proximity Read ↗

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.Semantic proximity Read ↗

Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast.Semantic proximity Read ↗

Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.Semantic proximity Read ↗

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.Semantic proximity Read ↗

Cdc14 Early Anaphase Release, FEAR, Is Limited to the Nucleus and Dispensable for Efficient Mitotic Exit.Semantic proximity Read ↗

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