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Article

Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.

Journal of cell science - 6 Nov 2019

Papini Diana, Fant Xavier, Ogawa Hiromi, Desban Nathalie, Samejima Kumiko, Feizbakhsh Omid, Askin Bilge, Ly Tony, Earnshaw William C, Ruchaud Sandrine

Abstract excerpt

Timely and precise control of Aurora B kinase, the chromosomal passenger complex (CPC) catalytic subunit, is essential for accurate chromosome segregation and cytokinesis. Post-translational modifications of CPC subunits are directly involved in controlling Aurora B activity. Here, we identified a highly conserved acidic STD-rich motif of INCENP that is phosphorylated during mitosis in vivo and by Plk1 in vitro...

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Topics

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Share to Cell Cycle
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytokinesis

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Share to Polo-Like Kinase 1

Share to rho-Associated Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 31601613
DOI: 10.1242/jcs.234401
PMCID: PMC7115952

Genes

INCENP
ROCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.PMID 31601613Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.Semantic proximity Read ↗

The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.Semantic proximity Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.Semantic proximity Read ↗

Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.Semantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint.Semantic proximity Read ↗

INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.Semantic proximity Read ↗

The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.Semantic proximity Read ↗

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