Article

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival

2023-04-06

Abstract excerpt

Intestinal epithelial transit amplifying cells are essential stem progenitors required for intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage from radiation and chemotherapy. Despite their critical roles in intestinal homeostasis and disease, few studies have described genes that are essential to transit amplifying cell function. We report that the RNA methyltransferase, ME...

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Literature Corpus work: 25ecb118-33b0-5ba7-a50d-6b523312b079
DOI: 10.1101/2023.04.06.535853

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