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Article

Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development.

Development (Cambridge, England) - 15 Oct 2025

Pan Yuwei, Wang Shiyang, Yang Wuqi, Wu Xi, Zhang Hanfu, Du Sujuan, Zhang Mingxin, Hou Liyuan, Plikus Maksim V, Shuai Jianwei, Lv Cong, Yu Lu, Yu Zhengquan

Abstract excerpt

Developing gut in mice undergoes rapid elongation during late embryogenesis, yet significantly slows down after birth. The precise regulatory mechanism of this dynamic morphogenetic process remains unknown. By utilizing single-cell RNA-sequencing analysis, we show that YAP activity in intestinal fibroblasts is the major molecular contributor to gut elongation. To determine how mesenchymal YAP activity is...

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Share to Cell Proliferation
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Gene Deletion

Share to Gene Expression Regulation, Developmental

Share to Intestines

Share to Protein Serine-Threonine Kinases

Share to YAP-Signaling Proteins

Source

Identifiers

PMID: 40521668
DOI: 10.1242/dev.204483

Genes

SLMAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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