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Article

MLL1 is required for maintenance of intestinal stem cells.

PLoS genetics - 1 Dec 2021

Goveas Neha, Waskow Claudia, Arndt Kathrin, Heuberger Julian, Zhang Qinyu, Alexopoulou Dimitra, Dahl Andreas, Birchmeier Walter, Anastassiadis Konstantinos, Stewart A Francis, Kranz Andrea

Abstract excerpt

Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells and adult homeostasis. Amongst many epigenetic marks, methylation of histone 3 lysine 4 (H3K4) is one of the most widely conserved and occupies a central position in gene expression. Mixed lineage leukemia 1 (MLL1/KMT2A) is the founding mammalian H3K4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histone-Lysine N-Methyltransferase

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Source

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Identifiers

PMID: 34860830
DOI: 10.1371/journal.pgen.1009250
PMCID: PMC8641872

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