Article

Integrative modeling reveals the molecular architecture of the Intraflagellar Transport A (IFT-A) complex

2022-07-05

Abstract excerpt

Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential for development and homeostasis in organisms ranging from algae to vertebrates. In humans, variants in genes encoding subunits of the cargo-adapting IFT-A and IFT-B protein complexes are a common cause of genetic diseases known as ciliopathies. While recent progress has been made in determining the atomic structure...

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Literature Corpus work: 25df868c-0f9c-5f84-9d36-0f3a3bab37d3
DOI: 10.1101/2022.07.05.498886

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