Article

In-cell structural insight into the asymmetric assembly of central apparatus in mammalian sperm axoneme

2024-08-06

Abstract excerpt

In motile cilia or flagella, the axoneme typically exhibits a “9+2” configuration, with the central apparatus (CA) consisting of extensively modified microtubules C1 and C2 to regulate ciliary motility. How C1 and C2 are interconnected asymmetrically remains unknown due to the lack of complete structural model of CA. Here, we utilized the in situ cryo-electron tomography approach to solve the in-cell structure of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 330cfa94-eb08-5084-9767-96e2e842696f
DOI: 10.1101/2024.08.06.606614

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In-cell structural insight into the asymmetric assembly of central apparatus in mammalian sperm axonemeDOI 10.1101/2024.08.06.606614Read

In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermiaSemantic proximity Read

The connecting cilium inner scaffold provides a structural foundation to maintain photoreceptor integritySemantic proximity Read

Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus.Semantic proximity Read

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathySemantic proximity Read

MYCBPAP is a central apparatus protein required for centrosome–nuclear envelope docking and sperm tail biogenesis in miceSemantic proximity Read

Structural organization of the C1b projection within the ciliary central apparatusSemantic proximity Read

CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertilitySemantic proximity Read

CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertilitySemantic proximity Read

Structural organization of the C1a-e-c supercomplex within the ciliary central apparatusSemantic proximity Read

3D structure and in situ arrangements of CatSper channel in the sperm flagellumSemantic proximity Read

An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexesSemantic proximity Read

Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2aSemantic proximity Read