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Article

Harnessing AlphaFold3 to elucidate BBSome structure and protein partners.

American journal of physiology. Cell physiology - 1 May 2026

Guo Deng Fu, Rouabhi Younes, Tollefson Mallory, Vorhies Kai, Rahmouni Kamal

Abstract excerpt

The BBSome, an eight-protein complex implicated in Bardet-Biedl syndrome (BBS), plays a crucial role in various cellular processes including ciliary function. Although important aspects of its structural organization and protein interactions have been elucidated, additional questions remain regarding how these features relate to cargo recognition and complex dynamics. Using AlphaFold3, we generated a structural...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41915029
DOI: 10.1152/ajpcell.00804.2025

Genes

BBS1
BBS4
BBS9
BBS2
BBS5
BBS7
MC4R
MRAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Harnessing AlphaFold3 to elucidate BBSome structure and protein partners.PMID 41915029Read ↗

Structure of the human BBSome core complex in the open conformationSemantic proximity Read ↗

Molecular Architecture of the Bardet-Biedl Syndrome Protein 2-7-9 SubcomplexSemantic proximity Read ↗

Structure and activation mechanism of the BBSome membrane-protein trafficking complexSemantic proximity Read ↗

Bardet-Biedl Syndrome 1 Mutations Differentially Impact BBSome Integrity and its Function in Ciliary TraffickingSemantic proximity Read ↗

Structural Characterization of Bardet-Biedl Syndrome 9 Protein (BBS9).Semantic proximity Read ↗

Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and ciliary trafficking.Semantic proximity Read ↗

MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis.Semantic proximity Read ↗

Exome sequencing of Bardet-Biedl syndrome patient identifies a null mutation in the BBSome subunit BBIP1 (BBS18).Semantic proximity Read ↗

Protein-Variant-Phenotype Study of NBAS Using AlphaFold in the Aspect of SOPH Syndrome.Semantic proximity Read ↗

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.Semantic proximity Read ↗

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.Semantic proximity Read ↗

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells.Semantic proximity Read ↗

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