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Article

Label-free proteomic comparison reveals ciliary and nonciliary phenotypes of IFT-A mutants.

Molecular biology of the cell - 1 Mar 2024

Leggere Janelle C, Hibbard Jaime V K, Papoulas Ophelia, Lee Chanjae, Pearson Chad G, Marcotte Edward M, Wallingford John B

Abstract excerpt

DIFFRAC is a powerful method for systematically comparing proteome content and organization between samples in a high-throughput manner. By subjecting control and experimental protein extracts to native chromatography and quantifying the contents of each fraction using mass spectrometry, it enables the quantitative detection of alterations to protein complexes and abundances. Here, we applied DIFFRAC to...

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Identifiers

PMID: 38170584
DOI: 10.1091/mbc.E23-03-0084
PMCID: PMC10916875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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