Article

Full-Length Structural Modeling of Mitofusins with AlphaFold Reveals a Novel Cross-Type Dimerization and Insights into Oligomerization

2026-04-13

Abstract excerpt

Mitochondrial dynamics, involving fission and fusion, are critical for the maintenance, function, distribution, and inheritance of mitochondria, allowing their morphology to adapt to the cell’s physiological needs. Mitofusins, large GTPase transmembrane proteins, play a role in this process by driving the tethering and fusion of mitochondrial outer membranes. Dysfunction in mitofusins has been associated with neur...

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Literature Corpus work: b17240b7-4e00-556b-8fb6-dfee6ce1284f
DOI: 10.64898/2026.04.10.717648

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