Structure of the human BBSome core complex in the open conformation

Abstract excerpt

The BBSome is a heterooctameric protein complex that plays a central role in primary cilia homeostasis. Its malfunction causes the severe ciliopathy Bardet-Biedl syndrome (BBS). The complex acts as a cargo adapter that recognizes signaling proteins such as GPCRs and links them to the intraflagellar transport machinery. The underlying mechanism is poorly understood. Here we present a high-resolution cryo-EM structu...

Topics

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• Bardet-Biedl Syndrome
• Cryoelectron Microscopy
• Crystallography, X-Ray
• Microtubule-Associated Proteins
• Models, Molecular
• Mutation
• Protein Binding
• Receptors, G-Protein-Coupled

Identifiers and source

Literature Corpus work

ac86989c-eded-5958-8d89-9c0efa3d63b3

DOI

10.1101/845982