Article

Genotyping TOMM40’523 Poly-T Polymorphisms Using Whole-Genome Sequencing

2025-04-25

Abstract excerpt

The TOMM40’523 poly-T repeat polymorphism (rs10524523), located in the TOMM40 gene and in linkage disequilibrium with APOE , has been associated with cognitive decline and Alzheimer’s disease (AD) progression. Accurate genotyping of this polymorphism is crucial for understanding its role in neurodegeneration. Challenges in processing whole-genome sequencing (WGS) data traditionally require additional PCR and targe...

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Literature Corpus work: 25c40d9c-245c-5c25-9b1f-935bd2f985af
DOI: 10.1101/2025.04.23.25326276

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