Article

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

2022-01-05

Abstract excerpt

The heterogeneity and evolution of AML blasts can render therapeutic interventions ineffective in a yet poorly understood patient-specific manner. To gain insight into the clonal heterogeneity of diagnosis (Dx) and relapse (Re) pairs, we employed whole-exome sequencing and single-cell RNA-seq to longitudinally profile two t(8;21) ( AML1-ETO = RUNX1-RUNX1T1 ), and four FLT3 -ITD AML cases. The single cell RNA d...

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Literature Corpus work: 2589f06b-5139-5e50-b40f-525a0d65d4ae
DOI: 10.1101/2022.01.04.474929

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