Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.

Blood cancer discovery - 1 Jan 2022

Petti Allegra A, Khan Saad M, Xu Ziheng, Helton Nichole, Fronick Catrina C, Fulton Robert, Ramakrishnan Sai M, Nonavinkere Srivatsan Sridhar, Heath Sharon E, Westervelt Peter, Payton Jacqueline E, Walter Matthew J, Link Daniel C, DiPersio John, Miller Christopher, Ley Timothy J

Abstract excerpt

To better understand clonal and transcriptional adaptations after relapse in patients with acute myeloid leukemia (AML), we collected presentation and relapse samples from six normal karyotype AML cases. We performed enhanced whole-genome sequencing to characterize clonal evolution, and deep-coverage single-cell RNA sequencing on the same samples, which yielded 142,642 high-quality cells for analysis. Identifying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to Karyotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Recurrence

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 35019859
DOI: 10.1158/2643-3230.BCD-21-0050
PMCID: PMC9924296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.PMID 35019859Read ↗

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.Semantic proximity Read ↗

Clonal Evolution of Pediatric Acute Myeloid Leukemia and Its Contribution to Disease RelapseSemantic proximity Read ↗

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemiaSemantic proximity Read ↗

Convergent epigenetic evolution drives relapse in acute myeloid leukemia.Semantic proximity Read ↗

Late relapse in acute myeloid leukemia (AML): clonal evolution or therapy-related leukemia?Semantic proximity Read ↗

Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemiaSemantic proximity Read ↗

Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression.Semantic proximity Read ↗

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemiaSemantic proximity Read ↗

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencingSemantic proximity Read ↗

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell GenomicsSemantic proximity Read ↗

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AMLSemantic proximity Read ↗

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.