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Article

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.

Molecular cancer - 19 Aug 2022

Zhai Yanan, Singh Prashant, Dolnik Anna, Brazda Peter, Atlasy Nader, Del Gaudio Nunzio, Döhner Konstanze, Döhner Hartmut, Minucci Saverio, Martens Joost, Altucci Lucia, Megchelenbrink Wout, Bullinger Lars, Stunnenberg Hendrik G

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood cancer that results from diverse genetic aberrations in the hematopoietic stem or progenitor cells (HSPCs) leading to the expansion of blasts in the hematopoietic system. The heterogeneity and evolution of cancer blasts can render therapeutic interventions ineffective in a yet poorly understood patient-specific manner. In this study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35986270
DOI: 10.1186/s12943-022-01635-4
PMCID: PMC9389773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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