Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression.

doi:10.1038/s41375-021-01338-7

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Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression.

Leukemia - 1 Oct 2021

Stetson L C, Balasubramanian Dheepa, Ribeiro Susan Pereira, Stefan Tammy, Gupta Kalpana, Xu Xuan, Fourati Slim, Roe Anne, Jackson Zachary, Schauner Robert, Sharma Ashish, Tamilselvan Banumathi, Li Samuel, de Lima Marcos, Hwang Tae Hyun, Balderas Robert, Saunthararajah Yogen, Maciejewski Jaroslaw, LaFramboise Thomas, Barnholtz-Sloan Jill S, Sekaly Rafick-Pierre, Wald David N

Abstract excerpt

The prognosis of most patients with AML is poor due to frequent disease relapse. The cause of relapse is thought to be from the persistence of leukemia initiating cells (LIC's) following treatment. Here we assessed RNA based changes in LICs from matched patient diagnosis and relapse samples using single-cell RNA sequencing. Previous studies on AML progression have focused on genetic changes at the DNA mutation...

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Identifiers

PMID: 34244611
DOI: 10.1038/s41375-021-01338-7
PMCID: PMC8807029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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