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A longitudinal single-cell atlas of treatment response in pediatric AML

16 Nov 2023

Abstract excerpt

Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular composition, driver alterations and prognosis. Characterization of this heterogeneity and how it affects treatment response remains understudied in pediatric patients. We used single-cell RNA sequencing and single-cell ATAC sequencing to profile 28 patients representing different pAML subtypes at diagnosis, remission and relapse....

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PMID: 37977148
DOI: 10.1016/j.ccell.2023.10.008

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