Article

Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of oxygen reactive species

2020-03-08

Abstract excerpt

The AMP-activated kinase (AMPK) is a major energy sensor metabolic enzyme that is activated early during T cell immune responses but its role in the generation of effector T cells is still controversial. Using both in vitro and in vivo models of T cell proliferation, we show herein that AMPK is dispensable for early TCR signaling and short-term proliferation but required for sustained long-term T cell proliferat...

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Identifiers and source

Literature Corpus work: 255259e9-30bf-59da-9b18-28dff611b017
DOI: 10.1101/2020.03.06.978791

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