Article
Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2013
Um Jee-Hyun, Brown Alexandra L, Singh Samarendra K, Chen Yong, Gucek Marjan, Lee Baeck-Seung, Luckey Megan A, Kim Myung K, Park Jung-Hyun, Sleckman Barry P, Gellert Martin, Chung Jay H
Abstract excerpt
The ability to sense metabolic stress is critical for successful cellular adaptation. In eukaryotes, the AMP-activated protein kinase (AMPK), a highly conserved serine/threonine kinase, functions as a critical metabolic sensor. AMPK is activated by the rising ADP/ATP and AMP/ATP ratios during conditions of energy depletion and also by increasing intracellular Ca(2+). In response to metabolic stress, AMPK...
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