Article

AMPK agonism optimizes the <i>in vivo</i> persistence and anti-leukemia efficacy of chimeric antigen receptor T cells

2024-09-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Chimeric antigen receptor T cell (CART) therapy has seen great clinical success. However, up to 50% of leukemia patients relapse and long-term survivor data indicate that CART cell persistence is key to enforcing relapse-free survival. Unfortunately, ex vivo expansion protocols often drive metabolic and functional exhaustion, reducing in vivo efficacy. Preclinical models hav...

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Literature Corpus work: 15da18e5-3618-5f91-9540-adb808c98409
DOI: 10.1101/2024.09.26.615290

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