Article

Enhance Memory CD8 <sup>+</sup> T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness

2025-04-16

Abstract excerpt

Memory CD8 + T cells are pivotal for long-term anti-tumor immunity due to their longevity and rapid response upon encountering tumor cells. Hematopoietic progenitor kinase 1 (HPK1), a member of the Ste20 family of kinases, restricts proximal T cell receptor (TCR) signaling and plays critical roles in T cell priming and activation. However, the impact of HPK1 on CD8 + T cell differentiation is not well understood...

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Literature Corpus work: ef5a6565-a07c-50e5-9072-3742cc1e5a0a
DOI: 10.1101/2025.04.10.648158

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