Article

Human cells based directed evolution of adenine base editors with improved efficiency

2021-05-06

Abstract excerpt

<title>Abstract</title> <p>Adenine base editors (ABE) are novel genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion in genomic DNA. However, the low activity of ABE remains a major bottleneck that precludes efficacious applications. To address this limitation, we developed a directional screening system in human cells to evolve the deaminase component of the ABE, and identifie...

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Literature Corpus work: baf1b9dd-ac50-55ef-a7e0-7f1c2fd4fc4a
DOI: 10.21203/rs.3.rs-418740/v1

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