Article

Loss of m6A unmasks a senescence-associated inflammatory program in human microglia

2026-07-08

Abstract excerpt

Chronic microglial inflammation and cellular senescence are hallmarks of the aging brain, yet the molecular events that lock microglia into durable inflammatory states remain poorly understood. Prior studies using genetic manipulation of METTL3 have implicated the RNA modification N6-methyladenosine (m6A) in senescence. However, because METTL3 also has m6A-independent functions, loss-of-function approaches cannot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24fb26b4-2ae2-5c24-a68f-bc217f5e3422
DOI: 10.64898/2026.07.06.736874

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of m6A unmasks a senescence-associated inflammatory program in human microgliaDOI 10.64898/2026.07.06.736874Read

Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element ActivationSemantic proximity Read

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype.Semantic proximity Read

Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs myelination and alters neuronal activitySemantic proximity Read

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's DiseaseSemantic proximity Read

Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysisSemantic proximity Read

Age-associated microglia populations identified from several single cell transcriptome dataSemantic proximity Read

Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomicsSemantic proximity Read

Transcriptional regulation of disease-relevant microglial activation programsSemantic proximity Read

HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathwaysSemantic proximity Read

Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesisSemantic proximity Read

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in miceSemantic proximity Read

Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal agingSemantic proximity Read