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HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

2025-05-08

Abstract excerpt

<h4>Summary</h4> HIV-associated neurocognitive disorders (HAND) persist in milder forms despite anti-retroviral therapy, leading to premature and exacerbated aging-related cognitive disorders. We investigated the interplay between HAND and aging in microglia, which constitute the main brain HIV reservoir. We compared the transcriptomic patterns associated with normal aging in healthy humans to those observed foll...

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Literature Corpus work
afdef36c-6aec-504a-bbdf-03782ffa1781
DOI
10.1101/2025.05.08.651477
Open publication

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HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathwaysDOI 10.1101/2025.05.08.651477
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