Article

Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis

2023-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Proteostasis is maintained through regulated protein synthesis and degradation and chaperone-assisted protein folding. However, this is challenging in neuronal projections because of their polarized morphology and constant synaptic proteome remodeling. Using high-resolution fluorescence microscopy, we discovered that hippocampal and spinal cord motor neurons of mouse and human origin localize a...

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Literature Corpus work: 24c69f0b-0122-52f0-a7e8-7da6b1b2db4b
DOI: 10.1101/2023.10.03.560761

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