Article

KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS

2025-11-02

Abstract excerpt

<h4>ABSTRACT</h4> Neuronal health depends on the precise transport and local translation of mRNAs to maintain synaptic function across highly polarized cellular architecture. While kinesin motor proteins are known to mediate mRNA transport, the specificity and direct involvement of individual kinesins as RNA-binding proteins (RBPs) remain unclear. Here, we demonstrate that KIF5A, a neuron-specific kinesin implica...

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Literature Corpus work: eef90c1e-c4d6-5f22-8da8-73a14e294de6
DOI: 10.1101/2025.10.31.685813

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