Article

The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity

2024-12-01

Abstract excerpt

<h4>ABSTRACT</h4> The degeneration of neurons in patients with amyotrophic lateral sclerosis (ALS) is commonly associated with accumulation of misfolded, insoluble proteins. Heat shock proteins (HSPs) are central regulators of protein homeostasis as they fold newly synthesized proteins and refold damaged proteins. Heterozygous loss-of- function mutations in the DNAJC7 gene that encodes an HSP co-chaperone were r...

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Literature Corpus work: 90bb596c-d30d-5725-9701-6d8e72a0af70
DOI: 10.1101/2024.12.01.626216

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