Article

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit

2020-02-10

Abstract excerpt

<h4>SUMMARY</h4> Protein synthesis must be finely tuned in the nervous system, as it represents an essential feature of neurodevelopmental gene expression, and dominant pathology in neurological disease. However, the architecture of ribosomal complexes in the developing mammalian brain has not been analyzed at high resolution. This study investigates the architecture of ribosomes ex vivo from the embryonic and p...

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Literature Corpus work: 7b434c71-b605-51cd-8cbc-9f7d08d6c56c
DOI: 10.1101/2020.02.08.939488

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