Article

Cell-type-specific adaptations to mitochondrial stress underly the neurological presentations of <i>MTRFR</i> mutations

2025-12-31

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial diseases are a group of heterogeneous genetic disorders that exhibit striking tissue specificity. Neurological involvement is among the most consistent features, yet the mechanisms that determine why selective neuronal populations are particularly vulnerable to mitochondrial dysfunction remain poorly understood. Mutations in MTRFR , a mitochondrial ribosome rescue factor, cause a...

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Literature Corpus work: 95c8c411-7d6f-5b05-97e5-f65f80d28abf
DOI: 10.64898/2025.12.30.696998

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