Article

Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS

2023-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Protein misfolding and mislocalization are common themes in neurodegenerative disorders, including the motor neuron disease, amyotrophic lateral sclerosis (ALS). Maintaining proteostasis is a crosscutting therapeutic target, including upregulation of heat shock proteins (HSP) to increase chaperoning capacity. Motor neurons have a high threshold for upregulating stress inducible HSPA1A, but const...

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Literature Corpus work: 49d81c4c-5664-52b8-99a8-e6dc2928cab8
DOI: 10.1101/2023.12.13.571549

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