Article

C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1

2023-03-31

Abstract excerpt

Ras GTPase-activating protein-binding protein 1 (G3BP1) is the key protein driving the formation of cytoplasmic stress granules (SGs) by liquid-liquid phase separation (LLPS). It is a switch-like protein held in a closed and inactive state by intramolecular electrostatic interactions competitively opened by RNA, activating the protein and initiating its LLPS. Here we show that C9orf72-derived arginine-rich dipepti...

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Literature Corpus work: 247980f7-64ae-5922-a1e0-dfbfe4f17abc
DOI: 10.1101/2023.03.31.535023

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