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Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTD

8 Jul 2020

Abstract excerpt

A hexanucleotide repeat expansion GGGGCC (G4C2) within chromosome 9 open reading frame 72 (C9orf72) is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). This seminal realization has rapidly focused our attention to the non-canonical translation (RAN translation) of the repeat expansion, which yields dipeptide-repeat protein products (DPRs). The mechanisms by...

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PMID: 32639008
DOI: 10.1042/etls20190167

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